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The hazard ratios HRs for each of the end points and safety events were estimated with a Cox proportional hazards regression in the propensity score-matched cohorts Table 3. We found no significant violation of the proportional hazards assumption for either exposure variable with respect to any of the main safety events P P P.10 for each. Compared with nsNSAIDs, coxibs HR, 1.28; 95% CI, 1.01-1.62 and opioids 1.77; 1.39-2.24 exhibited elevated relative risk for cardiovascular events. Gastrointestinal tract bleeding risk was reduced for coxib users HR, 0.60; 95% CI, 0.35-1.00 but was similar for opioid users 1.07; 0.65-1.76 compared with nsNSAID users. Coxib and nsNSAID use had a similar risk for fracture; however, fracture risk was elevated with opioid use HR, 4.47; 95% CI, 3.12-6.41 compared with nsNSAID of opioids HR, 1.68; 95% CI, 1.37-2.07 but not coxibs 1.12; 0.91-1.38 was associated with an increased risk of safety events requiring hospitalization compared with use of nsNSAIDs. Furthermore, we observed an increased risk of all-cause mortality among opioid users HR, 1.87; 95 CI, 1.39-2.53 but not coxib users 1.16; 0.85-1.57 compared with nsNSAID users.
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